GenomeMe社 リファレンスパネル
GenomeMe社のリファレンスパネルです。病理研究の抗体選定にご活用ください。
GenomeMe社の製品は試験研究用です。診断やその他の用途ではご使用いただけません。
（GenomeMe社のウェブサイトはこちら）
（IHC抗体およびHPVキットのご案内はこちら）
病理リスト
| 婦人科病理 | 皮膚病理 | 胃腸病理 | 泌尿生殖器病理 |
| 頭部および頸部病理 | 血液病理 | 血液病理 | 神経病理 |
| 小児科病理 | 肺病理 | 軟部組織病理 |
婦人科病理
乳癌
| CA15-3 | CA 19-9 | CK 5 | CK 7 | CK 20 | ER/PR | p63 | CD117 | |
| Infiltrating Ductal Carcinoma | + | – | – | + | – | + | – | – |
| Adenoid Cystic Carcinoma | + | + | + | + | – | – | + | + |
頚がん
| BCL2 | CK 17 | Ki-67 | MCM3 | |
| Cervical Intraepithelial Neoplasia | – | – | + | + |
| Tubo-Endometrial Metaplasia | + | + | – | – |
| Microglandular Hyperplasia | – | – | – | – |
頸部腫瘍
| CK 8 | CK 17 | p16 | |
| CIN I | -/+ | -/+ | + |
| CIN II | -/+ | + | + |
| CIN III | + | + | + |
卵巣がん
| CA-125 | CEA | PAX-8 | WT1 | |
| Ovarian CA, Serous | + | + | + | + |
| Ovarian CA, Mucinous | – | – | – | – |
| Ovarian CA, Endometrioid | + | – | + | – |
| Ovarian CA, Clear Cell | + | – | + | – |
胎盤栄養膜細胞
| 1st Trimester | 2nd Trimester | 3rd Trimester | ||||
| hCG | hPL | hCG | hPL | hCG | hPL | |
| Cytotrophoblast | – | – | – | – | – | – |
| Intermediate Trophoblast | 1-24% | 25-49% | -/+ | 50-74% | 1-24% | 1-49% |
| Syncytiotrophoblast | >75% | 1-24% | 25-49% | 50-74% | 1-24% | >75% |
胎盤栄養膜増殖
| CK OSCAR |
hCG | hPL | p57 | PLAP | Vimentin | |
| Partial Mole | + | -/+ | -/+ | + | + | – |
| Complete Mole | + | + | -/+ | – | -/+ | – |
| Choriocarcinoma | + | + | -/+ | – | -/+ | -/+ |
| Placental Site Tumor | + | +/- | + | + | + | + |
性索性間質腫瘍
| Calretinin | CD99 | CK 7 | EMA | Inhibin | MART-1 | Vimentin | |
| Granulosa Cell Tumors | + | + | – | – | + | + | + |
| Sertoli-Leydig Cell Tumors | + | + | + | – | + | + | + |
| Gynandroblastoma | + | -/+ | + | + | |||
| Gonadoblastomas | + | + | – | – | + | – | + |
子宮：栄養膜増殖
| CK Cocktail | hCG | hPL | p57 | PLAP | Vimentin | |
| Partial Mole | Strong, diffuse | Weak, diffuse | Weak, diffuse | + | + | – |
| Complete Mole | Strong, diffuse | Strong, diffuse | Weak, focal | – | Weak, focal | – |
| Choriocarcinoma | Strong, diffuse | Strong, diffuse | Weak, focal | – | Weak, focal | -/+ |
| Placental Site Tumor | Strong, diffuse | Strong, focal | Strong, diffuse | Strong, diffuse | Strong, diffuse |
皮膚病理
皮膚腫瘍
| AR | BCL2 | CD10 | CD34 | CK 15 | CK 19 | CK 20 | Ber-EP4 | |
| Basal Cell Carcinoma | + | + | + | – | – | + | – | + |
| Trichoepithelioma | – | + | – | + | + | + | + | + |
| Merkel Cell Carcinoma | – | + | – | – | – | + | + | + |
| Microcystic Adnexal Carcinoma | – | + | +/- | – | + | + | – | -/+ |
| Sebaceous Carcinoma | + | -/+ | +/- | – | – | – | + | |
| Sebaceous Adenoma | + | + | – | – | – | – | + |
メラノーマ
| Nestin | SOX-10 | HMB-45 | S-100 | |
| Desmoplastic Melanoma | + | + | – | + |
| Conventional Melanoma | + | + | + | + |
メルケル細胞がん vs 皮膚小細胞腫瘍
| CD117 | CK Cocktail |
CK 5&6 | CK 20 | Vimentin | Chromogranin A |
|
| Merkel Cell Carcinoma | + | + | – | + | – | + |
| Small Cell Carcinoma | +/- | + | – | – | – | + |
| Lymphoma | – | – | – | – | +/- | – |
| Small Cell Melanoma | + | – | – | – | + | – |
| Squamous Cell Carcinoma | – | + | + | – | – | – |
メルケル細胞がん vs 皮膚小細胞腫瘍 （続き）
| HMB-45 | Neurofilament | Synaptophysin | TTF-1 | CD45 | S-100 | |
| Merkel Cell Carcinoma | – | + | + | – | – | – |
| Small Cell Carcinoma | – | – | + | + | – | – |
| Lymphoma | – | – | – | – | + | – |
| Small Cell Melanoma | + | – | – | – | – | + |
| Squamous Cell Carcinoma | – | – | – | – | – | – |
皮膚付属器腫瘍
| CD15 | CK 7 | CK 20 | EMA | BRST-2 | S-100 | |
| Merkel Cell Carcinoma | – | – | + | + | – | – |
| Sebaceous Tumor | + | + | – | – | – | – |
| Apocrine Tumor | +/- | + | – | +/- | + | – |
| Eccrine Tumor | – | + | – | + | – | + |
皮膚：基底細胞がん VS 扁平上皮細胞がん
| BCL2 | CK 8&18 |
CK Cocktail |
EMA | Ep-CAM | MOC-31 | UEA-1 | |
| Basal Cell Carcinoma | + | -/+ | + | – | + | + | – |
| Squamous Cell Carcinoma | – | – | + | + | – | – | + |
皮膚：隆起性皮膚線維肉腫 vs Dermatofibroma Fibrous Histiocytoma
| CD10 | CD34 | CD163 | CK Cocktail |
Desmin | Factor XIIIa |
NGFR | p63 | S-100 | |
| DF-SP | +/- | + | – | – | – | – | + | – | – |
| DF-FH | + | – | – | – | – | + | – | – | – |
皮膚：パジェトイド腫瘍
| CEA | CK, HMW |
CK, LMW |
S-100 | Vimentin | |
| Melanoma | – | – | – | + | + |
| Paget’s Disease | + | – | + | -/+ | – |
| Bowen’s Disease | – | + | + | – | – |
紡錘細胞腫瘍
| MS Actin |
SM Actin |
ALDH1A1 | BG8 | CD10 | CD31 | CD34 | CD99 | Collagen IV |
CK 8&18 |
|
| Angiosarcoma | – | – | – | – | – | + | + | – | – | |
| Atypical Fibroxanthomas | + | + | + | – | + | – | – | + | – | – |
| Dermato broma Fibrous Histiocytoma | – | – | – | + | – | – | – | |||
| Dermatofibrosarcoma Protuberans | – | – | – | +/- | + | – | – | |||
| DF-FH | – | – | – | + | – | – | – | – | – | |
| DF-SP | – | – | – | – | +/- | – | + | – | – | – |
| Glomus Tumor | + | + | – | – | – | +/- | – | + | – | |
| Hemangioma | – | + | – | + | – | + | + | – | + | – |
| Hemangiopericytoma | – | – | + | – | + | + | – | |||
| Kaposi’s Sarcoma | – | + | – | – | – | + | + | – | +/- | – |
| Kaposiform Hemangioendothelioma | – | – | – | – | – | + | + | – | – | |
| Peripheral Nerve Sheath | + | – | + | – | – | – | – | + | + | |
| Smooth Muscle | + | + | + | – | – | – | -/+ | – | – | |
| Solitary Fibrous Tumor | – | – | + | – | – | – | + | +/- | – | – |
| Spindle Cell Melanoma | – | – | – | – | – | – | – | – | – | – |
| Spindle Squamous Cell Carcinoma | – | – | – | – | – | – | – | – | – | + |
| Squamous Cell Carcinoma | – | – | – | – | – | – | – | – |
紡錘細胞腫瘍 （続き）
| CK Cocktail |
Factor VIII |
Factor XIIIa |
FLI-1 | HHV-8 | NGFR | D2-40 | S-100 | STAT6 | |
| Angiosarcoma | – | + | + | – | – | +/- | – | – | |
| Atypical Fibroxanthomas | – | – | +/- | – | – | – | – | – | + |
| Dermato broma Fibrous Histiocytoma | + | – | – | – | – | – | |||
| Dermatofibrosarcoma Protuberans | – | + | – | – | – | ||||
| DF-FH | – | + | – | – | – | – | – | – | |
| DF-SP | – | – | – | – | + | – | – | – | |
| Glomus Tumor | – | – | – | – | – | – | – | – | |
| Hemangioma | – | + | + | – | – | – | – | – | |
| Hemangiopericytoma | – | + | – | – | – | – | + | ||
| Kaposi’s Sarcoma | + | +/- | + | + | – | + | – | – | |
| Kaposiform Hemangioendothelioma | – | – | + | – | – | – | – | ||
| Peripheral Nerve Sheath | – | – | – | – | – | + | + | +/- | – |
| Smooth Muscle | – | – | – | – | – | – | – | – | – |
| Solitary Fibrous Tumor | – | – | -/+ | – | – | – | – | – | |
| Spindle Cell Melanoma | – | – | – | + | – | + | + | + | – |
| Spindle Squamous Cell Carcinoma | + | – | – | – | – | + | – | – | |
| Squamous Cell Carcinoma | – | – | – | – | – | + | – | – |
胃腸病理
膨大部がん
| CDX-2 | MUC2 | CK 17 | MUC1 | |
| Intestinal Subtype | + | + | – | – |
| Ductal | – | – | + | + |
GIST
| CD34 | CD117 | DOG1 | |
| GIST, Kit Mutation | + | + | + |
| GIST, PDGFRA Mutation | – | – | + |
| GIST, Wild Type | +/- | + | + |
脾臓/脾臓腫瘍
| β-Catenin | CA 19-9 | D10 | CD56 | CDX-2 | Synaptophysin | CK 7 | CK 19 | E-cadherin | |
| Ductal Adenocarcinoma / Ductal Carcinoma | +/- | + | +/- | – | – | – | + | – | +/- |
| Pancreatic Adenocarcinoma | – | + | +/- | – | – | + | – | ||
| Pancreatic Endocrine Tumor | – | + | – | ||||||
| Acinar Cell Carcinoma | + | -/+ | +/- | – | – | – | – | + | + |
| Pancreatoblastoma | + | – | – | + | + | – | – | ||
| Neuroendocrine Tumor | + | +/- | – | + | + | +/- | – | ||
| Solid Pseudopapillary Tumor | + | – | + | + | – | – | +(核) | ||
| Islet Cells | + | – | – | + | + | – | – | ||
| Pancreatic Ducts | – | – | – | – | – | – | + | – | – |
泌尿生殖器病理
膀胱組織
| SM Actin |
MS Actin |
Calponin | Smoothelin | |
| Muscularis Mucosae | + | + | + | – |
| Muscularis Propria | + | + | + | + |
膀胱：形成異常 vs 反応性
| CD44 | CK 20 | CK 5&6 | Ki-67 | MCM3 | p53 | |
| Carcinoma-in-situ | – | + | – | + | + | + |
| Reactive Atypia | + | – | + | + | + | – |
| Normal Urothelium | + | + | -/+ | -/+ | -/+ | – |
がん
| CD10 | CD117 | CK 7 | CK, HMW | Ksp-cadherin | RCC | S100P | TFE3 | |
| Xp11 Tr RCC | + | -/+ | + | + | – | + | ||
| Clear Cell RCC | + | – | -/+ | – | -/+ | + | – | – |
| Papillary RCC | + | – | + | +/- | -/+ | + | – | – |
| Chromophobe RCC | +/- | + | + | – | + | + | – | – |
| Oncocytoma | + | + | -/+ | -/+ | + | – | – | – |
| Urothelial Carcinoma | + | +/- | + | +/- | – | – | + | – |
胚細胞腫瘍
| AFP | CD30 | CD117 | CK Cocktail |
EMA | GPC-3 | hCG | hPL | Inhibin | |
| Seminoma (Seminoma/Dysgerminoma) | – | – | + | – | – | – | – | – | – |
| Embryonal Carcinoma | – | + | – | + | – | – | – | – | – |
| Choriocarcinoma | – | – | – | + | + | + | + | + | – |
| Yolk Sac Tumor | + | – | -/+ | + | – | + | – | – | – |
| Granulosa Cell Tumor | – | – | – | – | – | – | – | – | + |
| Hypercalcaemic Small Cell Carcinoma | – | – | – | + | + | – | – | – | – |
| Mature Teratoma | +/- | – | – | + | + | – | – | -/+ | |
| Immature Teratoma | – | – | +/- | + | + | – | +/- | -/+ | |
| Carcinoid | – | – | – | + | – | – | – | – | – |
胚細胞腫瘍 （続き）
| Oct‐4 | PLAP | D2-40 | SALL4 | SOX-2 | Synaptophysin | Vimentin | |
| Seminoma (Seminoma/Dysgerminoma) | + | + | + | + | – | – | + |
| Embryonal Carcinoma | + | + | – | + | + | – | – |
| Choriocarcinoma | – | + | – | – | – | – | -/+ |
| Yolk Sac Tumor | – | -/+ | – | + | – | – | – |
| Granulosa Cell Tumor | – | – | +/- | – | – | + | |
| Hypercalcaemic Small Cell Carcinoma | – | – | + | – | – | ||
| Mature Teratoma | – | +/- | – | – | +/- | – | + |
| Immature Teratoma | – | – | – | +/- | + | – | + |
| Carcinoid | – | – | – | – | – | + | + |
生殖腺：胚細胞腫瘍 vs 体細胞腫瘍
| AFP | CD30 | CD117 | CK Cocktail |
EMA | GPC-3 | hCG | hPL | Inhibin | |
| Seminoma | – | – | + | – | – | – | – | – | – |
| Embryonal Carcinoma | – | – | + | – | – | – | – | – | |
| Choriocarcinoma | – | – | – | + | + | + | + | + | – |
| Yolk Sac Tumor | + | – | – | + | – | + | – | – | – |
| Somatic Carcinoma | – | – | – | + | + | – | – | – | – |
| Granulosa Cell Tumor | – | – | – | – | – | – | – | – | + |
| Hypercalcaemic Small Cell Carcinoma | – | – | – | + | + | – | – | – | – |
生殖腺：胚細胞腫瘍 vs 体細胞腫瘍 （続き）
| 43012 | PLAP | D2-40 | Vimentin | |
| Seminoma | + | + | + | + |
| Embryonal Carcinoma | + | + | – | – |
| Choriocarcinoma | – | + | – | -/+ |
| Yolk Sac Tumor | – | + | – | – |
| Somatic Carcinoma | – | – | -/+ | – |
| Granulosa Cell Tumor | – | – | +/- | + |
| Hypercalcaemic Small Cell Carcinoma | – | – | + | – |
頭部および頸部病理
副甲状腺腫瘍 vs 甲状腺腫瘍
| Calcitonin | PAX-8 | Chromogranin A |
PTH | S-100 | Galectin- 3 |
Synaptophysin | TTF-1 | |
| Parathyroid Tumors | – | + | + | + | – | – | + | – |
| Follicular Thyroid Tumors | – | + | – | – | +/- | + | – | + |
| Medullary Thyroid Cacinoma | + | – | + | – | – | – | + | + |
血液病理
B細胞リンパ腫
| Annexin AI |
BCL2 | BCL6 | BOB.1 | CDS | CD10 | CD11c | CD20 | CD23 | CD25 | |
| Burkitt Lymphoma | – | – | + | + | – | + | + | – | ||
| CLL/SLL | – | + | – | -/+ | + | – | -/+ | + | + | |
| Diffuse Large Cell Lymphoma | – | + | +/- | + | -/+ | + | – | |||
| Follicular | – | + | + | + | – | + | + | – | – | |
| Hairy Cell Leukemia | + | + | – | – | – | + | + | – | + | |
| Lymphoplasmacytic | – | + | – | + | – | – | – | + | – | – |
| Malt Lymphoma | + | -/+ | – | + | – | |||||
| Mantle Cell | – | + | – | -/+ | + | – | – | + | – | + |
| Marginal Zone | – | + | – | – | – | + | – | – | ||
| Marginal Zone BCL | – | + | – | -/+ | – | – | + | – | ||
| Splenic Marginal Zone | – | + | – | – | – | – |
B細胞リンパ腫 （続き）
| CD43 | CD45 | CD79a | Cyclin D1 |
FoxP1 | IgD | Kappa | Lambda | MUM1 | Octー2 | |
| Burkitt Lymphoma | + | + | – | + | – | +/- | -/+ | – | – | |
| CLL/SLL | + | + | + | – | – | + | +/- | -/+ | + | + |
| Diffuse Large Cell Lymphoma | – | + | + | – | + | – | +/- | -/+ | +/- | + |
| Follicular | + | + | – | – | + | +/- | -/+ | – | + | |
| Hairy Cell Leukemia | – | + | + | +(weak)/- | – | +/- | -/+ | +(weak)/- | ||
| Lymphoplasmacytic | + | + | – | – | – | +/- | -/+ | + | – | |
| Malt Lymphoma | + | – | + | – | ||||||
| Mantle Cell | + | + | + | + | – | + | -/+ | -/+ | – | + |
| Marginal Zone | + | + | + | – | + | -/+ | -/+ | + | + | |
| Marginal Zone BCL | + | – | -/+ | + | + | |||||
| Splenic Marginal Zone | + | – | – | +/- | + |
B細胞リンパ腫 （続き）
| p27 | PAX-5 | PD-1 | PU.1 | TRAcP | ZAP-70 | |
| Burkitt Lymphoma | – | + | – | – | – | |
| CLL/SLL | + | + | – | + | – | +/- |
| Diffuse Large Cell Lymphoma | – | + | – | + | – | – |
| Follicular | + | + | + | + | – | – |
| Hairy Cell Leukemia | – | + | – | + | – | |
| Lymphoplasmacytic | + | – | – | – | ||
| Malt Lymphoma | ||||||
| Mantle Cell | + | + | – | + | – | – |
| Marginal Zone | + | – | + | +/- | – | |
| Marginal Zone BCL | + | + | + | +/- | ||
| Splenic Marginal Zone | – |
c-Myc (びまん性大細胞型B細胞リンパ腫)
| BCL2 | CD10 | CD38 | CD44 | TCL1 | |
| Large B-cell Lymphoma with c-Myc Rearrangement | -/+ | + | + | – | + |
| Large B-cell Lymphoma with no c-Myc Rearrangement | + | +/- | – | + | -/+ |
赤血球
| CD71 | Glycophorin A |
Hemoglobin A |
Spectrin | |
| Erythroid Hyperplasia | + | + | + | + |
| Erythroid Hypoplasia | + | + | + | + |
| Acute Erythroid Leukemia | + | + | + | + |
| Extramedullary Hematopoiesis | + | + | + | + |
| Mature Erythrocytes | – | + | + | + |
組織球増殖
| CD1a | CD68 | CD163 | Factor XIIIa |
HAM-56 | lysozyme | S-100 | Vimentin | |
| Juvenile Xanthogranuloma | – | + | + | + | + | + | – | + |
| Langerhans Cell Histiocytosis | + | + | + | – | + | + | + | + |
| Dermatofibroma | – | + | – | + | – | – | – | + |
ホジキンリンパ腫 vs 非ホジキンリンパ腫
| EMA | Fascin | Granzyme B |
MUM1 | Octー2 | PU.1 | |
| Anaplastic Large Cell Lymphoma | + | – | + | – | – | – |
| Angioimmunoblastic T-cell Lymphoma | – | – | – | – | – | – |
| Hodgkin Lymphoma, Classic | – | + | – | + | – | – |
| Hodgkin Lymphoma, Nodular Lymphocyte Predominant | + | – | – | -/+ | + | + |
| T-cell Rich B-cell Lymphoma | -/+ | – | – | + | + | – |
| T-cell Rich LBCL | – | – | – | + | + | – |
イムノグロブリン（重鎖、軽鎖）
| IgA | IgD | IgG | IgM | Kappa | Lambda | |
| Cutaneous Lymphoma | – | – | – | – | +/- | -/+ |
| Myeloma | + | -/+ | + | -/+ | +/- | -/+ |
| Diffuse LBCL | – | – | + | + | +/- | -/+ |
| Marginal Zone Lymphoma | – | -/+ | – | + | +/- | -/+ |
| SLL/CLL | – | + | – | + | +/- | -/+ |
白血病
| CD13 | CD14 | CD16 | CD33 | CD34 | CD38 | CD71 | CD117 | CD163 | MPO | |
| Acute Myeloid Leukemia with Minimal Differentiation | + | + | – | + | + | + | – | + | – | – |
| Acute Myeloid Leukemia without Maturation | + | – | – | + | + | – | – | + | – | + |
| Acute Myeloid Leukemia with Maturation | + | – | – | + | + | – | – | + | – | + |
| Acute Myelomonocytic Leukemia | + | + | + | + | +/- | – | – | + | + | + |
| Acute Monoblastic and Monocytic Leukemia | + | + | + | + | -/+ | – | – | +/- | + | + |
| Acute Erythroid Leukemia | – | – | – | – | -/+ | – | + | +/- | – | – |
| Acute Megakaryoblastic Leukemia | +/- | – | – | +/- | – | – | – | – | – | – |
| Acute Basophilic Leukemia | + | – | – | + | +/- | – | – | – | – | – |
| Acute Panmyelosis with Myelofibrosis | + | – | – | + | + | – | – | + | – | – |
リンパ節
| CD1a | CD14 | CD21 | CD35 | CD68 | CD163 | Lysozyme | PD-1 | S-100 | |
| Reactive Histiocytosis | – | + | – | – | + | – | + | – | – |
| Langerhans Cell Histiocytosis | + | + | – | – | + | + | + | – | + |
| Sinus Histiocytosis with Massive Lymphadenopathy | – | + | – | – | + | + | + | – | + |
| Follicular Dendritic Cell Sarcoma | +/- | – | + | + | – | – | – | – | – |
| Dermatopathic Lymphadenitis | + | – | – | – | – | + | + | – | + |
リンパ芽球性リンパ腫 BCL vs TCL
| CD1a | CD3 | CD5 | CD7 | CD10 | CD19 | CD20 | CD74 | CD117 | PAX-5 | TdT | |
| Lymphoblastic BCL | – | – | – | – | +/- | + | +/- | + | – | + | + |
| Lymphoblastic TCL | +/- | + | +/- | + | + | – | – | – | – | – | + |
リンパ腫
| CD3 | CD20 | CD43 | CD45R | CD45RO | |
| Mature B-cell | – | + | – | + | – |
| Mature T-cell | + | – | + | – | + |
リンパ腫
| CD20 | CD30 | CD38 | CD45 | CD79a | CD138 | EMA | HHV-8 | MUM1 | PAX-5 | |
| Plasmablastic Lymphoma | – | + | + | – | + | + | + | – | + | – |
| Primary Effusion Lymphoma | – | +/- | +/- | + | – | + | +/- | + | + | – |
| Large B-cell Lymphoma arising in HHV8-associated Multicentric Castleman Disease | -/+ | -/+ | + | – | – | + | + | – | ||
| Extranodal Marginal Zone Lymphoma with Plasmacytoid Differentiation | – | + | + | + | + | – |
リンパ腫
| Granzyme B |
Perforin | TIA-1 | |
| NK/T Cell Lymphoma | + | + | + |
| Hepatosplenic T-cell Lymphoma | – | – | + |
| Cutaneous T-cell Lymphoma | + | + | + |
| EBV+ Systemic T-lymphoproliferative Disorders | + | + | + |
| T-cell Large Granular Lymphocytic Leukemia | + | + | + |
| Adult T-cell Leukemia/Lymphoma | – | – | – |
| Marginal Zone | – | – | – |
| Marginal Zone BCL | + | + | + |
リンパ腫
| BCL2 | BCL6 | CD15 | CD30 | Cyclin D1 |
Granzyme B |
IMP3 | MUM1 | |
| Classical Hodgkin’s Lymphoma | + | – | + | + | – | – | + | + |
| Lymphocyte Predominant Hodgkin Lymphoma | + | + | – | – | – | – | + | -/+ |
リンパ腫
| PAX-5 | SOX-11 | |
| Classical Hodgkin’s Lymphoma | + | – |
| Lymphocyte Predominant Hodgkin Lymphoma | + | – |
肥満細胞症
| CD2 | CD25 | CD117 | CD163 | Tryptase | |
| Mastocytosis / Systemic Mastocytosis | + | + | + | – | + |
| Mast Cell Leukemia | + | + | + | – | + |
| Reactive Mast Cells | – | – | + | + | + |
成熟B細胞リンパ腫
| Annexin A1 |
BCL2 | CD5 | CD10 | CD20 | CD23 | HGAL | LMO2 | Cyclin D1 |
|
| Follicular Lymphoma | – | +/- | – | +/- | + | – | + | + | – |
| Diffuse Large B-cell Lymphoma | – | + | -/+ | +/- | + | – | + | + | – |
| Small Lymphocytic Lymphoma | – | + | + | – | + | + | – | – | – |
| Mantle Cell Lymphoma | – | + | + | – | + | – | – | – | + |
| Marginal Zone Lymphoma | – | + | – | – | + | – | – | – | – |
| Hairy Cell Leukemia | + | + | – | – | + | – | – |
成熟B細胞腫瘍
| Annexin A1 |
CD10 | CD11c | CD25 | CD103 | CD123 | CyclinD1 | DBA44 | T-bet | TRAcP | |
| Hairy Cell Leukemia | + | + | + | + | + | + | +(weak)/- | +/- | + | +/- |
| Hairy Cell Leukemia Variant | – | – | + | – | +/- | +/- | – | +/- | ||
| Splenic Marginal Zone Lymphoma | – | – | -/+ | – | – | – | – | +/- | – | +/- |
NK細胞 白血病/リンパ種
| CD2 | CD3 | CD16 | CD56 | CD57 | Granzyme B |
Perforin | TIA-1 | |
| Aggressive NK-Cell Leukemia | + | + | + | + | – | + | + | + |
| T-Cell Large Granular Lymphocytic Leukemia | + | + | + | – | + | + | + | + |
| Extranodal NK/T-Cell Lymphoma, Nasal Type | + | + | – | + | – | + | + | + |
非ホジキンリンパ腫
| CD5 | CD10 | CD20 | CD23 | Cyclin D1 |
SOX-11 | |
| MCL | + | – | + | – | + | + |
| FL | – | + | + | – | – | – |
| SLL/CLL | + | – | + | + | – | – |
| MZL | – | – | + | – | – | – |
| LBL | – | +/- | + | – | – | – |
| BL | – | – | + | – | – | -/+ |
| CD5+ DLBCL | + | + | + | – | – | – |
| Blastoid Variant MCL | + | + | – | + | + |
形質細胞腫瘍とリンパ球増殖腫瘍
| CD19 | CD20 | CD43 | CD56 | CD79a | CD138 | Cyclin D1 |
EMA | MUM1 | |
| Plasma Cell Neoplasm | – | -/+ | – | + | + | + | -/+ | + | + |
| ALK + LBCL | – | – | – | – | + | – | + | + | |
| Plasmablastic Lymphoma | – | – | – | – | + | + | – | + | + |
| HHV Associated LBCL | +/- | +/- | – | – | – | – | – | – | – |
| Primary Effusion Lymphoma | – | – | – | – | – | + | – | + | + |
| Lymphoblastic Lymphoma | + | + | – | – | + | + | – | – | +/- |
| Splenic Marginal Zone Lymphoma | + | + | – | – | + | -/+ | – | – | +/- |
脾造血増殖 Splenic Hematopoietic Proliferations
| CD34 | CD68 | CD117 | Hemoglobin A |
MPO | |
| Chronic Myelogenous Leukemia | -/+ | + | +/- | – | + |
| Chronic Idiopathic Myelofibrosis | +/- | -/+ | – | + | |
| Myelodysplastic Syndrome | + | -/+ | – | ||
| Myelodysplastic/Myeloproliferative Disorders | – | + | – | – | + |
| Mastocytosis | – | + | – | + | |
| Erythroid Disorders | – | – | + | +/- | |
| Splenic Lymphoma | – | – | – | -/+ | |
| Acute Myeloid Leukemia | + | + | + | – | + |
| Polycythemia Vera | + | + | + |
T細胞リンパ腫
| CD56 | CD57 | Granzyme B |
PD-1 | Perforin | TCL1 | |
| Angioimmunoblastic | – | + | ||||
| Lymphoblastic | +/- | – | ||||
| Subcutaneous Panniculitis-Like | – | + | – | + | ||
| NK/T-cell Lymphoma | + | +/- | + | – | + | + |
| Cutaneous | + | -/+ | + | |||
| Peripheral, NOS | – | – | – | |||
| Mycosis Fungoides | – | +/- | – | – |
神経病理
脳：CNS腫瘍１
| EMA | CK, pan | GFAP | Vimentin | Olig2 | S-100 | |
| Astrocytoma | – | – | + | + | +/- | + |
| Oligodendrocytoma | – | – | – | + | + | – |
| Glioblastoma | – | + | +/- | + | + | + |
| Ependymoma | – | + | +/- | – | – | + |
| Meningloma | + | – | +/- | + | +/- | -/+ |
脳：CNS腫瘍２
| CK Cocktail |
EMA | GFAP | INI-1 | NGFR | Neurofilament | PR | S-100 | Synaptophysin | Vimentin | |
| Astrocytoma | – | – | + | + | + | – | – | + | – | + |
| Glioblastoma | – | – | + | + | – | – | – | + | – | + |
| Oligodendriglioma | – | – | – | + | – | – | – | + | – | + |
| Ependymoma | – | – | + | + | + | – | – | + | – | |
| Choroid Plexus Carcinoma | + | – | -/+ | + | – | – | – | + | + | +/- |
| Central Neurocytoma | – | – | – | + | + | – | – | – | + | – |
| Neuroblastoma | – | – | +/- | + | + | + | – | + | -/+ | |
| Pineocytoma | – | – | – | + | – | – | – | – | + | + |
| Meningloma | – | + | – | + | – | – | + | – | – | + |
| Schwannoma | – | – | + | + | + | – | – | + | – | + |
| Rhabdoid Tumors | + | + | – | – | +/- | +/- | +/- | + | ||
| Metastatic Carcinoma | + | + | – | + | – | – | -/+ | – | – | -/+ |
組織学的模倣による髄膜腫
| ALDH1A1 | CD34 | Claudin-1 | EMA | E-cadherin | GFAP | S-100 | STAT6 | |
| Meningothelial Meningioma | – | – | + | + | + | – | – | – |
| Atypical Meningioma | – | + | + | + | + | – | – | – |
| Fibrous Meningioma | – | – | – | + | + | – | + | – |
| Solitary Fibrous Tumor | + | + | – | – | – | – | – | + |
| Meningeal Hemangiopericytoma | + | + | – | – | – | – | – | -/+ |
| Schwannoma | – | +/- | – | + | + | + | – | |
後腹膜腫瘍
| CD99 | Chromogranin A |
GFAP | MBP | Neurofilament | NSE | PGP 9.5 | S-100 | Synaptophysin | |
| Neuroblastoma | – | + | +/- | – | + | + | + | – | + |
| Ganglioneuroblastoma | – | + | + | -/+ | + | + | + | + | + |
| Ganglioneuroma | – | + | + | + | + | + | + | + | + |
小児科病理
組織球増殖
| CD1a | CD68 | CD163 | Factor XIIIa |
HAM-56 | Lysozyme | S-100 | Vimentin | |
| Juvenile Xanthogranuloma | – | + | + | + | + | + | – | + |
| Langerhans Cell Histiocytosis | + | + | + | – | + | + | + | + |
| Dermatofibroma | – | + | – | + | – | – | – | + |
後腹膜病変
| Chromogranin A |
CD99 | GFAP | Neurofilament | NSE | PGP 9.5 | S-100 | Synaptophysin | |
| Neuroblastoma | + | – | -/+ | + | + | + | – | + |
| Ganglioneuroblastoma | + | – | + | + | + | + | + | + |
| Ganglioneuroma | + | – | + | + | + | + | + | + |
| Leiomyosarcoma | – | – | – | – | -/+ | -/+ | – | – |
| Rhabdomyosarcoma | – | – | – | – | – | + | – | – |
| Synovial Sarcoma | – | +/- | – | – | – | -/+ | – |
肺病理
肺腺がん vs 中皮腫
| BGB | Caldesmon | Calretinin | CEA | CK 5&6 | Ber-EP4 | |
| Adenocarcinoma | + | – | – | + | – | + |
| Mesothelioma | – | + | + | – | + | – |
肺腺がん vs 中皮腫 （続き）
| E-cadherin | HBME-1 | D2-40 | TAG-72 | TTF-1 | |
| Adenocarcinoma | + | – | – | + | + |
| Mesothelioma | – | + | + | – | – |
肺扁平上皮がん vs 腺がん
| CK 5&6 | Desmocollin3 | Napsin A |
p63 | SOX-2 | TTF-1 | |
| Lung Adenocarcinoma | – | – | + | -/+ | -/+ | + |
| Lung Squamous Cell Carcinoma | + | + | – | + | + | – |
胸膜：肺腺がん vs 中皮腫
| Caldesmon | Calretinin | CEA | CK 5 | CK 5&6 | Ep-CAM | E-cadherin | HBME-1 | Napsin A |
D2-40 | |
| Adenocarcinoma | – | – | + | – | – | + | + | – | + | – |
| Mesothelioma | + | + | – | + | + | – | – | + | – | + |
胸膜：肺腺がん vs 中皮腫（続き）
| TAG-72 | TTF-1 | TBM | WT1 | |
| Adenocarcinoma | + | + | – | – |
| Mesothelioma | – | – | + | + |
軟部組織病理
組織球性細胞損傷/樹状細胞損傷
| CD1a | CD21 | CD23 | CD35 | CD68 | CD163 | Langerin | Lysozyme | S-100 | |
| Langerhans Cell Histiocytosis | + | – | – | – | + | + | + | +/- | + |
| Rosai-Dorfman Disease | – | – | – | – | + | + | – | + | + |
| Follicular Dendritic Cell Sarcoma | – | + | + | + | +/- | +/- | – | – | – |
| Interdigitating Dendritic Cell Sarcoma | – | – | – | – | +/- | + | – | + | + |
| Histiocytic Sarcoma | – | – | – | – | + | + | – | + | +/- |
| Juvenile Disseminated Xanthogranuloma | – | – | – | – | + | + | – | + | +/- |
筋悪性腫瘍
| SM Actin |
MS Actin |
Myogenin | PGP 9.5 | Caldesmon | Myoglobin | Calponin | Vimentin | INI-1 | |
| Leiomyosarcoma | + | + | – | – | + | – | + | + | – |
| Rhabdomyosarcoma | -/+ | -/+ | + | + | – | + | – | + | + |
小型類円形細胞腫瘍
| MS Actin |
SM Actin |
Caldesmon | Calponin | CD45 | CD57 | CD99 | CK Cocktail |
FLI-1 | |
| Lymphoblastic Lymphoma | – | – | – | + | – | + | – | + | |
| Leiomyosarcoma | + | + | + | + | – | +/- | – | -/+ | – |
| Rhabdomyosarcoma | – | – | – | – | – | – | – | – | – |
| Neuroblastoma | – | – | – | – | + | – | – | – | |
| Embryonal Carcinoma | – | – | – | + | – | + | – | ||
| PNET/ES | – | – | – | + | + | -/+ | + | ||
| DSRCT | – | – | – | +/- | – | + | + | ||
| Medulloblastoma | – | – | – | + | – | – | – |
小型類円形細胞腫瘍（続き）
| INI-1 | Myogenin | Myoglobin | PGP 9.5 | Vimentin | WT1 | |
| Lymphoblastic Lymphoma | + | – | – | + | – | |
| Leiomyosarcoma | – | – | – | + | – | |
| Rhabdomyosarcoma | + | + | + | + | + | – |
| Neuroblastoma | + | – | – | + | + | – |
| Embryonal Carcinoma | + | – | – | + | – | – |
| PNET/ES | + | – | – | + | + | – |
| DSRCT | + | – | – | – | + | + |
| Medulloblastoma | + | – | – | |||
軟部組織新生物
| MS Actin |
SM Actin |
Calretinin | CD34 | CD56 | CK Cocktail |
Desmin | HMB-45 | S-100 | TFE3 | |
| Alveolar Soft Part Sarcoma | + | + | – | – | – | – | – | – | – | + |
| Clear Cell Sarcoma | – | – | – | – | – | – | – | + | + | – |
| Leiomyosarcoma | + | + | – | -/+ | + | -/+ | + | – | – | – |
| PEComa | – | + | + | – | + | – | – | + | + | – |
軟部組織肉腫
| MS Actin |
SM Actin |
Calponin | Calretinin | CD34 | CD56 | CD99 | CK Cocktail |
Desmin | EMA | |
| Alveolar Soft Part Sarcoma | + | + | – | – | – | – | – | – | – | |
| Clear Cell Sarcoma | – | – | – | – | – | – | – | |||
| Desmoplastic Small Round Cell | – | – | – | – | – | – | + | |||
| Epithelioid Sarcoma | -/+ | – | – | – | + | – | – | + | – | + |
| Leiomyosarcoma | + | + | -/+ | + | -/+ | + | -/+ | |||
| Mesenchymal Chondrosarcoma | – | – | + | -/+ | – | + | – | |||
| Myxoid Chondrosarcoma | – | +/- | + | -/+ | – | – | – | |||
| PEComa | – | + | + | – | – | – | – | |||
| PNET/ES | – | – | – | – | – | + | -/+ | |||
| Rhabdomyosarcoma | -/+ | -/+ | – | + | – | + | – | |||
| Synovial Sarcoma | – | – | – | +/- | – | + | + | + | – | + |
軟部組織肉腫（続き）
| Myogenin | S-100 | TFE3 | TLE1 | |
| Alveolar Soft Part Sarcoma | – | – | + | – |
| Clear Cell Sarcoma | + | – | – | |
| Desmoplastic Small Round Cell | – | – | – | |
| Epithelioid Sarcoma | – | – | – | |
| Leiomyosarcoma | – | – | ||
| Mesenchymal Chondrosarcoma | +/- | – | – | |
| Myxoid Chondrosarcoma | – | |||
| PEComa | – | – | – | |
| PNET/ES | + | – | – | |
| Rhabdomyosarcoma | + | – | ||
| Synovial Sarcoma | – | -/+ | – | + |
軟部組織腫瘍
| MS Actin |
SM Actin |
ALK | Calponin | CD34 | CD99 | CK Cocktail |
Desmin | EMA | FLI-1 | |
| Alveolar Soft Part Sarcoma | + | + | – | – | – | – | – | |||
| Clear Cell Sarcoma | – | – | – | – | – | – | ||||
| Desmoplastic Small Round Cell | – | – | – | – | – | + | + | – | ||
| Epithelioid Sarcoma | -/+ | – | – | + | – | + | – | + | ||
| Fibrous Histiocytoma | – | + | – | – | – | – | ||||
| Inｆlammatory Myo broblastic Tumor | + | + | + | – | – | – | ||||
| Leiomyosarcoma | + | + | + | – | -/+ | – | ||||
| Myxoid Chondrosarcoma | – | – | – | -/+ | – | – | – | |||
| PEComa | – | + | – | – | – | +/- | ||||
| PNET/ES | – | – | – | – | – | + | -/+ | – | + | |
| Rhabdomyosarcoma | -/+ | -/+ | – | – | – | – | ||||
| Synovial Sarcoma | – | – | – | – | + | + | – | + |
軟部組織腫瘍 （続き）
| INI-1 | Myogenin | PGP 9.5 | S-100 | TFE3 | TLE1 | |
| Alveolar Soft Part Sarcoma | – | + | – | |||
| Clear Cell Sarcoma | + | – | – | |||
| Desmoplastic Small Round Cell | – | – | – | |||
| Epithelioid Sarcoma | – | – | – | |||
| Fibrous Histiocytoma | – | – | – | |||
| Inｆlammatory Myo broblastic Tumor | – | – | – | |||
| Leiomyosarcoma | – | – | ||||
| Myxoid Chondrosarcoma | +/- | – | – | |||
| PEComa | – | – | – | |||
| PNET/ES | + | – | + | + | – | – |
| Rhabdomyosarcoma | + | + | + | |||
| Synovial Sarcoma | – | – | + |
血管腫瘍
| CD34 | ERG | Factor VIII |
FLI-1 | HHV-8 | D2-40 | |
| Hemangioma | + | + | + | + | – | – |
| Kaposi’s Sarcoma | + | + | + | + | + | + |
| Hemangioendothelioma | + | + | – | + | – | – |
| Angiosarcoma | + | + | + | + | – | +/- |
| Colorectal Adenocarcinoma | – | – | – | -/+ | – | – |
| Invasive Ductal Carcinoma | – | – | -/+ | – | – | |
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